pentobarbital will reduce the level or effect of midostaurin by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Prevent or Use Alternate Drug. Potent CYP3A4 inducers may reduce midostaurin concentrations causing diminished efficacy.pentobarbital and olopatadine intranasal the two boost sedation. Stay clear of or Use Alternate Drug. Coadmin